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Best Weed for Anxiety in 2024: Top Medical Cannabis Strains To Relieve Stress & Anxiety

The Fresno Bee - 2/26/2024

Did you know that around 4% of the population is diagnosed with an anxiety disorder currently, and many of these people are on anti-anxiety medications, which help them with managing anxiety and heightened stress?

While medications can reduce anxiety and provide anxiety relief, the same is true for smoking cannabis due to different cannabis compounds that are beneficial to mental health.

This being said, we look into the best marijuana strains for stress and anxiety, and the ultimate winner is the Northern Lights, thanks to its profound relaxing effect, causing relaxation on the body and mind.

Our selection of cannabis strains for anxiety management also includes six other options, and each one is briefly reviewed in the sections below, so let’s go!

First Look

1. Northern Lights – Best for Anxiety Overall

Northern Lights is a hybrid Indica strain crafted to induce an unparalleled sense of serenity and calm, which makes it one of the favorites among medical marijuana consumers.

Its soothing properties make it ideal for alleviating physical pain, insomnia, and muscle tension, making it particularly well-suited for evening use.

Furthermore, its reputation for promoting mental well-being makes it a preferred option for individuals grappling with anxiety and depression, offering a well-deserved relief from the demands of daily life with its potent physical effects.

Notably, Northern Lights boasts high THC levels, typically ranging from 16% to an impressive 33%, contributing to its reputation for inducing profound relaxation and tranquility.

The strain’s flavor profile is equally captivating, with a delicate hint of pine complementing its initial sweet and earthy notes. This results in a delightful fusion of flavors inherited from its equally remarkable parent marijuana varieties, Thai and Afghani.

Where to Buy

Top-grade quality Northern Light seeds are available at Seed Supreme, one of the leading names among recreational and medical marijuana consumers due to its assortment that boasts over 4,000 options.

Shopping at the largest seed bank in the United States means benefiting from free shipping and free seeds on bigger orders, an impressive Germination Guarantee, and a great discount when you buy marijuana seeds for the first time.

>> Check the best price for Northern Lights seeds at Seed Supreme

2. White Widow – Intense and a Longer-Lasting Psychoactive Effect

White Widow is another highly sought-after hybrid Indica strain boasting 60% Indica genetics from its prominent lineage.

Renowned for its profound physical and psychoactive effects, White Widow offers users deep relaxation and clear-headed euphoria, making it an ideal choice for unwinding after a demanding day or seeking relief from chronic pain, stress, or anxiety.

With THC content ranging from a manageable 19% to an astounding 25%, this strain is favored among medical marijuana consumers for its effects that may reduce stress and anxiety.

Its earthy, sweet, and spicy flavor profile, coupled with its unlikely sensitivity to environmental factors, makes White Widow a top choice for both new and experienced cannabis consumers who may consume it in higher doses to experience more intense and longer-lasting effects.

Different effects may be experienced when consuming White Widow in low doses, including mild sedation that may help when you feel like you are about to have a panic attack. Read this White Widow strain review for more information.

Where to Buy

For those interested in acquiring White Widow, ILGM offers a selection of feminized and autoflower seeds, making it a prime destination for beginners and experienced growers.

At ILGM, new customers can get $10 off their next order, while on the site, you will find a range of Bogo deals, thanks to which you can get the best marijuana varieties for mental health at a discounted price.

>> Check the best price for White Widow seeds at ILGM

3. Gorilla Glue #4 – Deep Body and Mind Relaxation

Gorilla Glue #4 emerges as another popular Indica strain with an illustrious lineage derived from its potent parents, Chocolate Diesel, Sour Diesel, Chem’s Sister, and Sour Dubb.

The effects of Gorilla Glue #4 can be described as a harmonious fusion of euphoria and profound physical and mental relaxation.

As a potent hybrid strain, it strikes an ideal balance between the soothing bodily effects of Indica and the energizing cerebral effects of any popular Sativa-dominant strain, inducing feelings of euphoria and heightened mental acuity.

Medical marijuana patients hold Gorilla Glue #4 in high regard for its stress-alleviating and pain-relieving properties, which are particularly beneficial for individuals grappling with chronic physical discomfort.

Renowned for its high THC content, typically ranging from 25% to 30%, Gorilla Glue #4 stands as one of the most potent Indicas available, promising consumers a profound sense of tranquility and euphoria, facilitating relaxation and the release of accumulated stress and tension.

Delighting the senses with a delightful blend of earthy, pine, and sweet chocolate notes, Gorilla Glue #4 offers a complex and captivating flavor profile.

Where to Buy

You can shop for high-quality Gorilla Glue #4 seeds at Homegrown Cannabis Co. If you use the letsgrow promo code during checkout, you benefit from free shipping.

In addition, you can get free seeds of Gorilla Glue #4 on any purchase if you use the gg4auto promo code during checkout.

>> Check the best price for Gorilla Glue #4 seeds at Homegrown Cannabis Co.

4. Wedding Cake – Ideal for Those with Social Anxiety

Wedding Cake is a top-rated Indica strain renowned for its exceptional therapeutic benefits and effects.

This strain is highly regarded for its mood-elevating properties, making it an effective treatment for reducing stress, anxiety, and depressive symptoms alongside social anxiety.

Additionally, individuals suffering from migraines, chronic pain, and muscle spasms can find relief through its potent analgesic and anti-inflammatory properties.

With THC levels ranging between 20% and 25%, Wedding Cake offers a well-balanced, energizing high suitable for both daytime and nighttime use.

Users often report feeling a euphoric cerebral sensation, making it an ideal choice for those seeking inspiration or a productivity boost in addition to natural anxiety management.

The captivating scent of Wedding Cake, characterized by subtle notes of vanilla and spices, exudes a sweet and earthy aroma reminiscent of freshly baked cookies.

Upon consumption, expect a delightful fusion of tart and sweet notes harmonizing with the classic Girl Scout Cookie flavor.

Where to Buy

Seedsman is the best place to shop for Wedding Cake seeds. If you use the WELOVESEEDS10 promo code, Seedsman reviews note that you can qualify for a 10% discount on your order.

Shopping at Seedsman also means benefitting from a 100% Germination Guarantee on each order and fast shipping regardless of your location in the USA.

>> Check the best price for Wedding Cake seeds at Seedsman

5. Granddaddy Purple – Anxiety-Free Restful Sleep

Now we discuss the ultimate Indica strain for maintaining a healthy sleep cycle without anxious thoughts bothering you: Granddaddy Purple.

Those interested in medical use have recognized its exceptional capacity to deliver a subtly uplifting cerebral experience, making it an ideal choice for alleviating stress, anxiety, and depression with minimal adverse effects.

This potent hybrid, leaning heavily towards Indica, induces a profoundly relaxing and tranquil high, often described by consumers as providing complete relaxation and a gentle euphoric sensation that alleviates tension and anxiety.

Granddaddy Purple consistently boasts a high THC content, ranging from 17 to 23%, placing it among the most potent Indicas available.

This attribute makes it highly sought after by individuals seeking relief from pain, stress, and sleeplessness, as its potent THC content significantly contributes to its profoundly calming and soothing effects.

The strain’s flavor profile is also unparalleled, combining sweet, fruity notes with subtle earthy undertones reminiscent of juicy grapes and berries with a hint of earthy pine.

Where to Buy

Royal Queen Seeds is a renowned seed bank where you can purchase top-grade Granddaddy Purple seeds for recreational and medical cannabis use.

The company’s overall customer rating is very high, 4.7/5, and this high rating is based on over 35,700 verified customer reviews. If you place your review on the website, you get a 10% discount on your next order.

>> Check the best price for Granddaddy Purple seeds at Royal Queen Seeds

6. Girl Scout Cookies – Relaxation Mixing with Upliftment

You can experience an immediate cerebral and uplifting high with the Girl Scout Cookies strain, thanks to its prominent Sativa strain lineage.

At the same time, this cannabis strain is 60% Indica, making it an excellent choice for those who are looking to treat anxiety and stress with cannabis use.

This strain offers stimulating effects that can elevate mood, boost creativity, and induce euphoria.

Additionally, its predominant Indica genes provide exceptional stress relief and deep relaxation, making it an excellent choice for alleviating stress, anxiety, and chronic pain.

With a high THC content of up to 28%, Girl Scout Cookies is a well-balanced blend of the invigorating sativa Durban Poison and the relaxing indica OG Kush.

Its flavor profile is genuinely exceptional, combining earthy and sweet notes to satisfy even the most demanding cannabis enthusiasts.

However, the main appeal of Girl Scout Cookies is its ability to help with anxiety, making it a preferred choice among those who struggle with feeling anxious quite often.

Where to Buy

Herbies are the best weed seed bank to shop for Girl Scout Cookies seeds, and the renowned seed bank houses a variety of other cannabis varieties, many of which are beneficial to people who experience symptoms of anxiety.

If you pick FedEx as your preferred shipping method, you get your seeds between two and five business days. On the site, you can easily calculate shipping costs based on your order.

>> Check the best price for Girl Scout Cookies seeds at Herbies

7. Hindu Kush – 100% Indica for Ultimate Stress-Relief

Experience the calming and relaxing effects of the Hindu Kush, a potent 100% Indica strain with up to 19% THC.

This Indica strain is favored by those seeking relief from chronic pain, muscle spasms, and other symptoms, with users praising its effectiveness. With its earthy, woodsy, and slightly floral flavor profile, Hindu Kush offers a unique sensory experience.

Additionally, Hindu Kush is celebrated for its potential to induce a profound sense of introspection, making it an ideal companion for meditation and mindfulness practices.

The strain’s ability to enhance sensory perception and promote heightened awareness further contributes to its allure among those seeking a transformative and reflective experience.

It is especially cherished for recreational use among those looking to experience that couch-lock vibe.

Where to Buy

Suppose you are interested in growing Hindu Kush on your own. In that case, the top-grade Hindu Kush seeds are available at MSNL Seeds, another renowned seed bank that definitely deserves your attention.

It is important to note that MSNL Seeds offers free seeds for each order. In addition, if you pay for your order using a bank transfer, you instantly qualify for a 10% discount, which is an excellent way to start your shopping adventure.

>> Check the best price for Hindu Kush seeds at MSNL Seeds

What Is Weed for Anxiety?

The potential benefits of weed for the treatment of anxiety have been a subject of continuous discussion in the medical profession.

Many people are looking to marijuana as a possible treatment for their anxiety problems as its legalization for both medical and recreational usage grows.

Research indicates that cannabis may be able to help some people with their anxiety problems, especially strains rich in both THC and CBD [1].

The possible anxiolytic effects of cannabinoids like THC and CBD, which are present in the cannabis flower, have been researched as well [2].

As a result, there is increasing curiosity about using cannabis as a natural anxiety relief substitute, but more research is necessary.

Either way, there is no denying that cannabis products in different forms may be beneficial to people with other medical conditions due to the primary psychoactive compound.

>> Check the best price for Northern Lights seeds at Seed Supreme

How Cannabis Affects Anxiety?

While there are many compounds found in cannabis, the most researched ones in association with anxiety are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD).

The psychoactive ingredient in cannabis, THC, has been linked to effects that are both anxiolytic and anxiogenic.

The intricate relationship that exists between THC and the endocannabinoid system is essential for controlling anxiety reactions [3], often resulting in less anxiety and lowered depression, even when consumed in lower doses.

Conversely, the non-intoxicating substance CBD and CBD products have drawn interest due to its possible anxiolytic effects [1].

Research indicates that CBD may have anxiolytic effects by modulating the endocannabinoid system and interacting with serotonin receptors [4].

The interactions that occur between THC and CBD, as well as other cannabinoids and terpenes related to regular cannabis use, contribute to the variety of relieving effects that people experience with anxiety, ultimately helping them cope better.


The appeal of cannabis strains for anxiety is their capacity to induce feelings of peace and relaxation with stress relief without having the overpowering adverse effects that are sometimes connected to prescription drugs [5].

These strains provide a soothing release from the entangling grip of anxiety by restoring harmony and balance through their targeting of the body’s endocannabinoid system [3].

The wide variety of strains available, each with a distinct combination of terpenes and cannabinoids, is one of the main benefits of using cannabis for anxiety.

There’s a strain out there just right for you, whether you want the soft hug of a CBD-dominant strain or the mild exhilaration of a well-balanced hybrid.

Additionally, these cannabis strains’ natural origins present a compelling substitute for man-made medications, embracing the purest form of nature’s therapeutic potential.

The holistic method is appealing to individuals who are looking for a more natural and long-lasting route to well-being, devoid of the possible hazards linked to conventional anxiety drugs.

Cannabis strains for anxiety can not only help people relax but also improve their mood and sense of well-being, giving them the ability to take back control of their emotional and mental states.

>> Check the best price for Northern Lights seeds at Seed Supreme

How to Choose

With so many varieties available, choosing the strain that will best meet your unique needs is crucial.

The effects of various cannabis strains on anxiety vary. Certain strains have the ability to promote peace and relaxation, while others may make anxiety worse.

Since Indica-dominant strains are typically linked to drowsiness and relaxation, they are suitable for reducing anxiety.

Conversely, Sativa-dominant strains could be stimulating and uplifting, which could make some people feel more anxious, especially those with higher levels of THC.

Aromatic substances called terpenes are present in cannabis and give it a distinct flavor and aroma. Additionally, they are essential to the general effects of many cannabis varieties.

Look for strains with high myrcene, linalool, and limonene content to relieve anxiety. Myrcene, which has sedative qualities, can help you relax, and limonene and linalool can help with anxiety and mood enhancement.

One non-euphoric ingredient in cannabis that may have anxiolytic effects is cannabidiol or CBD.

Higher CBD and lower THC strains are frequently chosen for their ability to reduce anxiety since CBD can balance out the euphoric effects of THC and offer a more tranquil and balanced experience.

Safety and Side Effects

When using cannabis to treat anxiety, safety is the main priority.

To reduce the chance of contamination or exposure to hazardous materials, it is imperative to make sure the product is purchased from a reliable and lawful supplier.

Before taking cannabis for anxiety, anyone with a history of substance addiction or mental health issues should use caution and speak with a healthcare provider.

Anxiety-related side effects of cannabis use include increased heart rate, psychosis, vertigo, and cognitive decline, especially when consuming varieties with high levels of cannabinoids.

Depending on the user’s tolerance level, the particular strain, and the dosage, these effects can change.

People should be mindful of these possible adverse effects, keep a careful eye on how they respond, and avoid consuming high doses initially.

Including marijuana in an anxiety treatment regimen needs to be done so carefully and under a doctor’s supervision.

Individual health states, current treatment regimens, and any drug interactions should all be considered.

CBD for Stress Relief

CBD interacts with the body’s endocannabinoid system [3], which is essential for controlling stress, anxiety, and mood, according to a number of studies.

CBD modifies the brain’s neurotransmitter and receptor function by supporting emotional equilibrium and relaxation.

Moreover, CBD is readily incorporated into daily routines by individuals due to its various forms. There is a delivery strategy for everyone, whether topical creams, sweets, capsules, or CBD oil.

Choosing premium products from reliable businesses is crucial when selecting a CBD product.

Look for goods that have undergone independent testing for purity and potency to be sure you are getting a reliable and safe product.

Unlike traditional pharmaceuticals, CBD, even in small doses, offers a natural alternative without the risk of harmful side effects or dependency, and this is another benefit of incorporating CBD into your daily regime, the best marijuana strains we discussed earlier.

>> Check the best price for Northern Lights seeds at Seed Supreme

When to Talk to a Doctor

It is critical to know when to discuss anxiety with a doctor to receive the care and support required to control your symptoms and enhance your general health.

You want to speak with a healthcare provider if you discover that your symptoms are severely affecting your capacity to perform at your job, school, or in your relationships, and they are present on the majority of days over a period of weeks or months.

Anxiety disorders can manifest as symptoms including persistent concern, restlessness, irritability, trouble concentrating, and disturbed sleep.

In addition to causing mental anguish, anxiety can also cause physical symptoms such as trembling, perspiration, fast heartbeat, muscle strain, exhaustion, and gastrointestinal problems.

It is recommended to seek medical attention to rule out any underlying health concerns and receive appropriate therapy for your anxiety if you have persistent anxiety along with these physical symptoms.

Professional intervention is required if your anxiety is creating a significant impairment in your day-to-day functioning.

Examples of such impairments include poor performance at work, difficulty interacting with others, or avoidance of routine activities.

If anxiety is left unmanaged, it can get worse over time and negatively affect your general health, but talk therapy may be of great help, as well as specific lifestyle changes.


For more information on marijuana use for anxiety, make sure you check out our FAQs section below.

What Strain of Weed Is Most Muscle Relaxing?

The most relaxing weed strain, especially if you are looking to help your tense muscles, is Gorilla Glue #4, which also positively impacts the mind.

Is Indica or Sativa Bad for Anxiety?

While both Indica and Sativa cannabis varieties may help individuals struggling with anxiety, Sativa varieties may not be the best choice as many do not induce relaxation, which is commonly associated with Indica varieties.

What Strain Makes You Feel Motivated?

The Girl Scout Cookies weed strain can make you feel more motivated, in addition to boosting inspiration and creativity.

What Is the Best Strain for Anxiety and ADHD?

The best strain for anxiety and ADHD is White Widow, which is known for its relaxing effects that mix with mood upliftment and greater focus and energy, which may be beneficial to those diagnosed with ADHD.

What Strain Helps with Relaxation?

The strain that helps with relaxation is Northern Lights. This is a potent Indica hybrid with a higher level of THC known for inducing profound body and mind relaxation.

How Much THC Is Safe for Anxiety?

For a safe THC experience, whether you want to engage in vaping cannabis or smoking, you want to stick to consuming between 5 and 10mg of THC at a time.

What Is the Best THC for Anxiety and Stress?

The best THC for anxiety and stress is found in Indica-dominant varieties, such as Northern Lights, White Widow, Hindu Kush, Girl Scout Cookies, and Gorilla Glue #4.

Does CBD Work for Anxiety?

Studies have indicated that CBD may help improve sleep quality, reduce the impact of traumatic memories, and alleviate the physical symptoms often associated with anxiety, such as muscle tension and restlessness.

Why Does Sativa Calm Me Down?

Sativa strains are known for their uplifting and energizing properties.

Still, they also contain specific terpenes and cannabinoids that contribute to their potential to soothe anxiety and make you calmer and at peace.

Which Terpene Is Best for Anxiety?

Beta-caryophyllene stands out as the best terpene against anxiety.

This aromatic compound not only contributes to the distinctive scent of cannabis but also exhibits anti-anxiety properties by interacting with the endocannabinoid system.

Final Verdict

While anxiety is a normal part of everyone’s life, dealing with anxiety presents a series of challenges, and managing anxiety levels is not something that comes easily.

Thankfully, Indica strains like Northern Lights available at Seed Supreme have shown to be helpful in promoting calmness and relaxation when it comes to treating anxiety.

The earthy aroma and mild exhilaration of this and other featured strains may provide a route towards peace and inducing calmness and relaxation when you need it the most, such as when struggling with heightened stress and anxiety.

Hence, we recommend you take a step towards a more relaxed and balanced life and let these remarkable strains accompany you on this anxiety-free adventure.


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